Human Leucine-rich repeat-containing G-protein coupled receptor 4


G Protein-Coupled Receptor 48, GPR48, BNMD17

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CSH3081PR pdf (datasheet)


50 µg


$8,780.00 BUY


LGR4 encodes the Leucine-rich repeat-containing G-protein coupled receptor 4. In contrast to classical G-protein coupled receptors, LGR4 does not activate heterotrimeric G-proteins to transduce the signal. It binds R-spondins and activates the Wnt signaling pathway which is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. LGR4 also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Mutations in this gene have been associated with osteoporosis. An important paralog of this gene is LGR6. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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