Human Leucine-rich repeat-containing G-protein coupled receptor 5


G Protein-Coupled Receptor 49, GPR49, G-Protein Coupled Receptor HG38, G-Protein Coupled Receptor 67, FEX

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CSH3103PR pdf (datasheet)


50 µg


$8,780.00 BUY


LGR5 encodes the Leucine-rich repeat-containing G-protein coupled receptor 5, a member of GPCR class A receptor proteins. The encoded protein is a receptor for Rspondins and is involved in the canonical Wnt signaling pathway. Upon binding to Rspondins (RSPO1, RSPO2, RSPO3 or RSPO4), LGR5 associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, LGR5 does not activate heterotrimeric Gproteins to transduce the signal. This receptor is involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. An important paralog of this gene is LGR6. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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