Human Metabotropic glutamate receptor 4


Glutamate Metabotropic Receptor 4, GPRC1D, MGLUR4, MGlu4

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CSH1069PR pdf (datasheet)


50 µg


$8,780.00 BUY


GRM4 encodes the protein known as Metabotropic glutamate receptor 4 (mGluR4). The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4 (this receptor), GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Activation of GRM4 has potential therapeutic benefits in the treatment of Parkinson's disease. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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