Human Metabotropic glutamate receptor 5


Glutamate Metabotropic Receptor 5, Protein Phosphatase 1, Regulatory Subunit 86, PPP1R86, GPRC1E, MGLUR5, MGlu5

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CSH3017MP pdf (datasheet)


10 mg


$1,695.00 BUY


GRM5 encodes the protein known as Metabotropic glutamate receptor 5 (mGluR5). The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 (this receptor), receptors that have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Metabotropic glutamate receptor 5 plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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