Human N-formyl peptide receptor 2

Synonyms:

FMLP-related receptor I, FMLP-R-I, Formyl peptide receptor-like 1, HM63, Lipoxin A4 receptor, LXA4 receptor, RFP, ALXR

Cat. No.:

CSH1139PR pdf (datasheet)

Quantity/Size:

50 µg

Price:

$8,780.00 BUY

Description:

FPR2 encodes the cell surface G-protein coupled receptor protein N-formyl peptide receptor 2, a low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to this receptor causes activation of neutrophils, mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Th activation of this receptor could result in an antiinflammatory outcome counteracting the actions of proinflammatory signals such as leukotriene B4. The FPR2 receptor is expressed on human neutrophils, eosinophils, monocytes, macrophages, T cells, synovial fibroblasts, and intestinal and airway epithelium. The formyl peptide receptor family, FPR1, FPR2 and FPR3 are Gi-proteincoupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defense and inflammation. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

Uniprot ID:

P25090

Data PDF:

CSH1139