Human N-Formyl Peptide 3 Receptor


Formyl Peptide Receptor-Like 2, FMLP-Related Receptor II, FMLP-R-II, RMLP-R-I

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CSH3055PR pdf (datasheet)


50 µg


$8,780.00 BUY


FPR3 encodes the cell surface G-protein coupled receptor protein N-formyl peptide receptor 3, a low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to this receptor causes activation of neutrophils, mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. But the overall function of FPR3 is unclear. Compared to FPR1 and FPR2, FPR3 is highly phosphorylated (a signal for receptor inactivation and internalization) and more localized to small intracellular vesicles. This suggests that FPR3 rapidly internalizes after binding its ligands and thereby may serve as a "decoy" receptor to reduce the binding of its ligands to FRP1 and FRP2 receptors. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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