Mouse Anti-Human Ang-2 Clone B-C57 Azide Free mAb

Molecule:

Angiopoietin-2

Species:

Human

Cat. No.:

CDM479 pdf (datasheet)

Quantity/Size:

500 μg

Price:

$575.00 BUY

Concentration:

1 mg/ml

Description:

Angiopoetin-2 (Ang-2) is a key regulator of angiogenesis, exerting context-dependent effects on endothelial cells (ECs). Ang-2 binds the endothelial-specific receptor tyrosine kinase 2 (Tie2) and acts as a negative regulator of Ang-1/Tie2 signaling during angiogenesis, thereby controlling the responsiveness of ECs to exogenous cytokines. Recent data from tumors indicate that under certain conditions Ang-2 can also promote angiogenesis. Human and mouse Ang-2 share 85% amino acid (aa) identity and Ang-2 is approximately 60% identical to its homolog, Ang-1. Ang-2 contains an N-terminal coiled-coil domain, 58-254 amino acids and a C-terminal fibrinogen-like domain, 281-467 aa.

Entrez Symbol:

ANGPT2

Uniprot Name:

Angiopoetin-2

Uniprot ID:

O15123

Data PDF:

CDM479

Specificity:

Recognizes both natural and recombinant human Ang-2

Host Species:

Mouse

Immunogen:

Recombinant human Angiopoietin-2

Isotype:

IgG2b Kappa light chain

Clone:

B-C57

Conjugate:

Unconjugated

Formulation:

Sterile-filtered PBS. Carrier and preservative-free.

Application:

ELISA

Storage/Stability:

Store in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.