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The monoclonal antibody is directed against the human CD28 antigen, which is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. CD28, when stimulated by its ligands B7-1 (CD80) or B7-2 (CD86) provides the co-stimulatory "second signal" required for T cell activation.
The monoclonal antibody is directed against the CD28 antigen, which is expressed on a subpopulation of human T cells and activated B cells. It has been shown that CD28 positive cells are cytotoxic T lymphocyte precursors. The monoclonal antibody does not react with B cells, granulocytes and monocytes.