Mouse Anti-Human CD45 (Clone B-A11) mAb, Azide Free

Molecule:

CD45

Synonyms:

Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200

Species:

Human

Cat. No.:

CDM187B pdf (datasheet)

Quantity/Size:

500 μg

Price:

$650.00 BUY

Concentration:

1 mg/ml

Description:

The mouse monoclonal antibody recognizes human CD45, a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. CD45 is a receptor type PTP, with an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. CD45 also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.

Entrez Symbol:

PTPRC

Uniprot Name:

Receptor-type tyrosine-protein phosphatase C

Uniprot ID:

P08575

Data PDF:

CDM187

Specificity:

Recognizes Leucocyte Common Antigen (LCA) with different isoforms of 180-190-205-220 kDa

Host Species:

Mouse

Immunogen:

Thymus cells and Jurkat cell line

Isotype:

IgG1 Kappa light chain

Clone:

B-A11

Formulation:

Sterile filtered PBS, carrier and preservative free.

Purification:

Affinity chromatography

Application:

FC

Storage/Stability:

Store at 2-8°C for up to 1 year or in working aliquots at -20°C to -80oC. Avoid repeated freeze-thaw cycles.