Mouse Anti-Human CD59 (Clone MEM-43) mAb, Azide Free

Synonyms:

1F5, EJ16, EJ30, EL32, HRF-20, HRF20, MAC-IP, MACIF

Species:

Human

Cat. No.:

CDM062A pdf (datasheet)

Quantity/Size:

200 µg

Price:

$500.00 BUY

Description:

The monoclonal antibody recognizes CD59, a cell surface glycoprotein that regulates complement-mediated cell lysis, and is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction.

Entrez Symbol:

CD59

Uniprot Name:

CD59 glycoprotein

Uniprot ID:

P13987

Data PDF:

CDM062

Specificity:

Reacts with a PI-linked glycoprotein, molecular weight 18-20 kDa, found in all types of leucocytes including platelets.

Host Species:

Mouse

Immunogen:

Thymocytes and T lymphocytes

Isotype:

IgG2a kappa light chain

Clone:

MEM-43

Formulation:

Sterile filtered PBS, treated to remove endotoxins. Carrier and preservative free.

Application:

FC, IHC, IP

Application notes:

Use for identification of CD59+ cells by immunofluorescence and immunoperoxidase methods on cryostat sections.

Storage/Stability:

Store at 2-8°C for up to 1 year or in working aliquots at -20°C to -80oC. Avoid repeated freeze-thaw cycles.