Mouse Anti-Human Fas / CD95 (Clone B-D29) mAb, Azide Free

Molecule:

Fas/CD95

Synonyms:

Tumor necrosis factor receptor superfamily member 6, TNFRSF6, FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen

Species:

Human

Cat. No.:

CDM070A pdf (datasheet)

Quantity/Size:

200 μg

Price:

$390.00 BUY

Concentration:

1 mg/ml

Description:

Upon ligand binding, Fas forms the death-inducing signaling complex (DISC), a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors. The DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis. Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. This event is also mimicked by binding of an agonistic Fas antibody.

Entrez Symbol:

FAS

Uniprot Name:

Tumor necrosis factor receptor superfamily member 6

Uniprot ID:

P25445

Data PDF:

CDM070

Specificity:

Recognizes the CD95, APO1 antigen, a 45 kDa protein

Host Species:

Mouse

Immunogen:

Recombinant human Fas

Isotype:

IgG1 Kappa light chain

Clone:

B-D29

Formulation:

Sterile filtered PBS, treated to remove endotoxins. Carrier and preservative free.

Application:

ELISA, FS

Application notes:

Inhibits FasL induced apoptosis.

Storage/Stability:

Store at 2-8°C for up to 1 year or in working aliquots at -20°C to -80oC. Avoid repeated freeze-thaw cycles.