Mouse Anti-Human GM-CSF mAb, Azide Free

Molecule:

GM-CSF

Synonyms:

Granulocyte-macrophage colony stimulating factor, Colony-stimulating factor, CSF

Species:

Human

Cat. No.:

CMB209A pdf (datasheet)

Quantity/Size:

50 μg

Price:

$490.00 BUY

Description:

Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), macrophage CSF (M-CSF), and Interleukin-3 (IL-3, Multi CSF). Both GM-CSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, G-CSF and M-CSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors.

Recent studies revealed that GM-CSF also had pro-inflammatory functions and contributed to the pathogenicity of Th17 cells in the development of Th17-mediated autoimmune diseases. GM-CSF inhibition in some animal models of autoimmune diseases showed significant beneficial effects. Therefore, several agents targeting GM-CSF are being developed and are expected to be a useful strategy for the treatment of autoimmune diseases.

Entrez Symbol:

CSF2

Uniprot Name:

Granulocyte-macrophage colony-stimulating factor

Uniprot ID:

P04141

Data PDF:

CMV209

Specificity:

Human GM-CSF

Host Species:

Mouse

Immunogen:

Recombinant human GM-CSF

Isotype:

IgG1

Clone:

MM0315-4D44

Formulation:

Sterile filtered PBS, carrier and preservative free.

Purification:

Protein G affinity chromatography, from cell culture supernatant

Application:

ELISA, FC, Neutralizing

Application notes:

Use as capture antibody paired with CMV208

Storage/Stability:

Store in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.