Mouse Anti-Human IL-6ST / CD130 (Clone B-S12) Azide Free mAb

Molecule:

IL6-ST

Synonyms:

IL-6 Signal Transducer, IL-6R subunit beta, IL-6RB CD130, CDW130, gp130

Species:

Human

Cat. No.:

CDM019 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$390.00 BUY

Concentration:

1.0 mg/ml

Description:

The monoclonal antibody recognizes human CD130, also known as Interleukin 6 Signal Transducer or gp130. IL-6ST is a signal transducer shared by many cytokines, including interleukin 6 (IL-6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). The protein functions as a part of the cytokine receptor complex and its activation is dependent upon the binding of cytokines to their receptors.

Entrez Symbol:

IL6ST

Uniprot Name:

Interleukin-6 receptor subunit beta

Uniprot ID:

P40189

Data PDF:

CDM019

Specificity:

Recognizes gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.

Host Species:

Mouse

Immunogen:

Natural soluble gp130

Isotype:

IgG1

Clone:

B-S12

Conjugate:

Unconjugated

Formulation:

Sterile-filtered PBS and treated to remove endotoxins. Carrier and preservative free.

Purification:

Ion exchange chromotography

Application:

FC, FS , IP , WB

Application notes:

Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation. Activates cells carrying gp130

Storage/Stability:

Store at 2-8°C for 12 months. For longer storage, freeze aliquots at -20°C. Avoid repeated freeze-thaw cycles.