Mouse Anti-Human IL-12 p40 + p70 Clone B-P40 Azide Free mAb

Molecule:

IL-12

Synonyms:

Interleukin-12 subunit beta, IL-12B, IL-12 p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, NK cell stimulatory factor chain 2, NKSF2

Species:

Human

Cat. No.:

CDM281B pdf (datasheet)

Quantity/Size:

500 μg

Price:

$650.00 BUY

Concentration:

1 mg/ml

Description:

The monoclonal antibody recognizes human IL12 (p40/p70), a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12p70 is the biologically active form and is composed of two subunits: IL-12p35 (also named IL-12A) and IL-12p40 (also named IL-12B). The p35 subunit has homology to IL-6, while p40 has homology with IL-23. The p40 subunit has been found to be expressed in a higher excess over p70. It is present in serum and plasma as a monomer, a heterodimer with IL-12p35 (biologically active IL-12p70) or heterodimer with IL-23p19 (IL-23). The subunits are genetically unrelated and regulated independently: IL-12p40 is produced constitutively and in excess of IL-12p35 and IL-23p19.

Entrez Symbol:

IL12B

Uniprot Name:

Interleukin-12 subunit beta

Uniprot ID:

P29460

Data PDF:

CDM281

Specificity:

Recognizes both native and recombinant human IL-12 p40 + p70

Host Species:

Mouse

Immunogen:

Recombinant human IL-12

Isotype:

IgG1 Kappa light chain

Clone:

B-P40

Formulation:

Sterile-filtered PBS, carrier and preservative free.

Purification:

Ion exchange Chromatography

Application:

ELISA, FC

Application notes:

ELISA: Use as a Capture Antibody at 0.5 - 2.5 µg/ml in a human IL-12 sandwich immunoassay in combination with biotinylated human IL-12 p40 + p70 Detection Antibody (Cat No CDM430).

Storage/Stability:

Store at 2-8°C for up to 1 year or in working aliquots at -20°C to -80oC. Avoid repeated freeze-thaw cycles.