Mouse Anti-Human IL-15 Azide free Clone B-E29 Blocking mAb

Molecule:

IL-15

Synonyms:

IL15, IL-15, IL 15, IL15

Species:

Human

Cat. No.:

CDM282 pdf (datasheet)

Quantity/Size:

0.5 mg

Price:

$650.00 BUY

Concentration:

1 mg/ml

Description:

The monoclonal antibody recognizes human Interleukin-15 (IL-15), a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities; both bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. Studies of the mouse counterpart suggested that IL-15 may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.

Entrez Symbol:

IL15

Uniprot Name:

Interleukin-15

Uniprot ID:

P40933

Data PDF:

CDM282

Specificity:

Native and Recombinant Human IL-15

Host Species:

Mouse

Immunogen:

Recombinant Human IL-15

Isotype:

IgG1

Clone:

B-E29

Conjugate:

Unconjugated

Formulation:

Liquid in PBS. Sterile filtered and treated to remove endotoxins. Carrier and preservative free.

Purification:

Ion-exchange chromatography

Application:

FS

Application notes:

Blocks IL-15 induced proliferation on Kit 225 cell line.

Storage/Stability:

Store at 2-8°C for up to one year. For longer term, store in working aliquots at -20°C to -80°C. Avoid repeated freeze-thaw cycles.