Mouse Anti-Human IL-17A Clone B-B51 Azide Free mAb

Molecule:

IL-17A

Synonyms:

IL17A, IL17, CTLA8, IL-17, IL-17A

Species:

Human

Cat. No.:

CDM114 pdf (datasheet)

Quantity/Size:

500 μg

Price:

$650.00 BUY

Concentration:

1 mg/ml

Description:

Mouse Anti-Human IL-17A Clone B-B51 Neutralizing Azide Free monoclonal antibody. Interleukin-17 (IL-17, or IL-17A) is the original member of the IL-17 family of cytokines. IL -17A is involved in inducing and mediating proinflammatory responses, commonly associated with allergic responses and induces the production of many other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), chemokines (including IL-8, GRO-α and MCP-1) and prostaglandins (e.g. PGE2) from many cell types (fibroblasts, endothelial cells, epithelial cells, keratinocytes and macrophages). IL-17A function is also essential to a subset of CD4+ T-Cells called T helper 17 (Th17) cells. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. Product: Derived from a hybrid of Myeloma X63/AG.8653 x Balb/c node cells.

Entrez Symbol:

IL17A

Uniprot Name:

Interleukin-17A

Uniprot ID:

Q16552

Data PDF:

CDM114

Specificity:

Human | Recognizes both recombinant and natural human IL-17A

Host Species:

Mouse

Immunogen:

Recombinant human IL-17A

Isotype:

IgG2b

Clone:

B-B51

Conjugate:

Unconjugated

Formulation:

Liquid in phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Purification:

Ion exchange chromatography

Application:

NT

Application notes:

Neutralizes the bioactivity of IL-17A on keratinocytes cell line HaCaT (measurement of beta defensin-2 production)

Storage/Stability:

Stable at 2-8°C for 12 months. For longer storage, freeze aliquots at -20°C. Avoid repeated freeze-thaw cycles.