Mouse Anti-Human IL-17A (Clone B-B51) mAb, Azide Free

Molecule:

IL-17A

Synonyms:

Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8

Species:

Human

Cat. No.:

CDM114B pdf (datasheet)

Quantity/Size:

500 μg

Price:

$650.00 BUY

Concentration:

1 mg/ml

Description:

Interleukin-17 (IL-17, or IL-17A) is the original member of the IL-17 family of cytokines. IL-17A is involved in inducing and mediating proinflammatory responses, commonly associated with allergic responses and induces the production of many other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), chemokines (including IL-8, GRO-α and MCP-1) and prostaglandins (e.g. PGE2) from many cell types (fibroblasts, endothelial cells, epithelial cells, keratinocytes and macrophages). IL-17A function is also essential to a subset of CD4+ T-Cells called T helper 17 (Th17) cells. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Entrez Symbol:

IL17A

Uniprot Name:

Interleukin-17A

Uniprot ID:

Q16552

Data PDF:

CDM114

Specificity:

Recognizes both recombinant and native human IL-17A

Host Species:

Mouse

Immunogen:

Recombinant human IL-17A

Isotype:

IgG2b Kappa light chain

Clone:

B-B51

Formulation:

Sterile filtered PBS, carrier and preservative free.

Purification:

Ion exchange chromatography

Application:

ELISA, ELISPOT, FS

Application notes:

Inhibits the bioactivity of IL-17A on keratinocytes cell line HaCaT (measurement of beta defensin-2 production)