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Mouse Anti-Human IL-23A Clone B-Z23 mAb

Molecule:

IL-23A

Synonyms:

P19; SGRF; IL-23; IL-23A; IL23P19

Species:

Human

Cat. No.:

CDM115 pdf (datasheet)

Quantity/Size:

500 μg

Price:

$570.00 BUY

Concentration:

1 mg/ml

Description:

Mouse Anti-Human IL-23A Clone B-Z23 Azide Free mAb

This antibody can be used as a Capture Antibody in a human IL-23 sandwich immunoassay to detect human IL-23 in combination with biotinylated human IL-23 Detection Antibody (Cat No CDM433).

Background: Interleukin 23A is a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.

Entrez Symbol:

IL23A

Uniprot Name:

Interleukin-23 subunit alpha

Uniprot ID:

Q9NPF7

Data PDF:

CDM115

Specificity:

Human | Recognizes both recombinant and natural human IL-23, p19 sub-unit

Host Species:

Mouse

Immunogen:

Recombinant human IL-23 (sub-unit p19)

Isotype:

IgG1

Clone:

B-Z23

Conjugate:

Unconjugated

Formulation:

Liquid in phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Purification:

Ion exchange chromatography

Application:

ELISA

Application notes:

Neutralizes the bioactivity of rhIL-23 on mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production). Suitable for immunochemistry on paraffin embedded section.
ELISA Capture Antibody: 2.5 - 5 µg/ml

Storage/Stability:

Stable at 2-8°C for 12 months. For longer storage, freeze aliquots at -20°C. Avoid repeated freeze-thaw cycles.