Mouse Anti-Human IL-23 alpha p19 (Clone B-Z23) mAb, Azide Free

Molecule:

IL-23A

Synonyms:

Interleukin-23 subunit alpha, P19, IL23P19

Species:

Human

Cat. No.:

CDM115B pdf (datasheet)

Quantity/Size:

500 μg

Price:

$650.00 BUY

Concentration:

1 mg/ml

Description:

Interleukin 23A is a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.

Entrez Symbol:

IL23A

Uniprot Name:

Interleukin-23 subunit alpha

Uniprot ID:

Q9NPF7

Data PDF:

CDM115

Specificity:

Recognizes both recombinant and native human IL-23, p19 sub-unit

Host Species:

Mouse

Immunogen:

Recombinant human IL-23 (sub-unit p19)

Isotype:

IgG1 Kappa light chain

Clone:

B-Z23

Formulation:

Sterile filtered PBS, carrier and preservative free.

Purification:

Ion exchange chromatography

Application:

ELISA, FS , IHC-P, Neutralizing

Application notes:

Inhibits the bioactivity of recombinant human IL-23 on C57BL/6 mouse splenocytes as demonstrated by mouse IL-17 and IL-22 production.


ELISA: Use as a Capture Antibody at 2.5 - 5 µg/ml for human IL-23 sandwich ELISA in combination with biotinylated human IL-23 Detection Antibody (Cat No CDM433).

Storage/Stability:

Store at 2-8°C for up to 1 year or in working aliquots at -20°C to -80oC. Avoid repeated freeze-thaw cycles.