Mouse Anti-Human IL-6 Clone B-E4 Biotin Detection Monoclonal Antibody.

This Antibody can be used as Detection Ab in a human IL-6 sandwich immunoassay to detect human IL-6 in combination with human IL-6 Capture Antibody (Cat No. CDM402 and CDM265).

Background: IL-6 is a cytokine that functions in inflammation and the maturation of B cells. In addition, it has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The malfunction of IL-6 has been associated with a wide range of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.