Mouse Anti-Human Interleukin-6 (Clone UC-6) mAb

Molecule:

IL-6

Synonyms:

IL-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2

Species:

Human

Cat. No.:

CMI262 pdf (datasheet)

Quantity/Size:

0.5 mg

Price:

$690.00 BUY

Description:

IL-6 (a glycosylated protein of 21–28 kDa) is produced by a broad spectrum of cells in response to a wide variety of stimuli. The cytokine is produced by innate immune cells (e. g., macrophages, dendritic cells, and mast cells), B cells, by some CD4 effector T helper (Th) cells and also by a variety of non-leukocyte cells (e.g. endothelial cells, fibroblasts, astrocytes, epithelial cells). A common feature of many of the stimuli that activate IL-6 is that they represent tissue damage or stress (e.g., UV, irradiation, reactive oxygen species, microbial products, viruses, or other pro-inflammatory cytokines). Down regulation of IL-6 production plays critical roles in the pathogenesis of several disease processes, including human myeloma and several autoimmune diseases, such as rheumatoid arthritis, systemic-onset juvenile chronic arthritis (JCA), osteoporosis, and psoriasis

Uniprot Name:

Interleukin-6

Uniprot ID:

P05231

Data PDF:

CMI262

Specificity:

Binds with similar affinity to native and recombinant human IL-6. Shows full cross-reactivity with IL-6 from several Old World monkeys.

Host Species:

Mouse

Isotype:

IgG1

Clone:

UC-6

Formulation:

Lyophilized from sterile-filtered PBS containing 125 mM Trehalose

Purification:

Ion exchange chromatography.

Reconstitution:

Centrifuge vial briefly before opening. Reconstitute with 0.5 ml sterile distilled water, containing 0.02% sodium azide to prevent bacterial growth (recommended). Precaution: Sodium azide is a poisonous and hazardous substance which should be handled by trained staff only.

Application:

ELISPOT, NT

Storage/Stability:

Lyophilized product is stable for at least one year at 2-8°C. After reconstitution, the contents can be safely stored at 2-8°C for one month or for one year in working aliquots at -20°C to -80°C. Avoid repeated freeze-thaw cycles.