Mouse Anti-Human NKp30 (Clone B-S30) mAb, Azide Free

Molecule:

NKp30

Synonyms:

Natural cytotoxicity triggering receptor 3, Activating natural killer receptor p30, CD337, Natural killer cell p30-related protein, NKp30, NK-p30

Species:

Human

Cat. No.:

CDM323A pdf (datasheet)

Quantity/Size:

200 μg

Price:

$390.00 BUY

Concentration:

1 mg/ml

Description:

Natural cytotoxicity receptors (NCRs), are unique markers that regulate natural killer (NK) cell cytotoxicity and cytokine production. The NCR family are comprised of three type I transmembrane (TM) receptors, termed NKp46, NKp44, and NKp30, which are encoded by the genes, NCR1, NCR2, and NCR3, respectively. Even though the NCRs were discovered based on their ability to induce NK cell cytotoxicity of monoclonal antibody (mAb)-coated tumor cell targets, the blocking of individual NCR activity using soluble mAbs had only a mild effect on NK cell cytotoxicity and different tumor cells varied in their susceptibility. Combinations of soluble mAbs to the NCRs were found to have a much stronger blocking effect for selected tumor cell-lines indicating that the NCRs can cooperate with each other to mediate NK cell cytotoxicity of certain tumor cell-types.

Entrez Symbol:

NCR3

Uniprot Name:

Natural cytotoxicity triggering receptor 3

Uniprot ID:

O14931

Data PDF:

CDM323

Specificity:

Recognizes both native and recombinant NKp30

Host Species:

Mouse

Immunogen:

Recombinant human NKp30/Fc

Isotype:

IgG2b Kappa light chain

Clone:

B-S30

Formulation:

Sterile filtered PBS, carrier and preservative free.

Purification:

Ion exchange chromatography

Application:

ELISA

Storage/Stability:

Store at 2-8°C for up to 1 year or in working aliquots at -20°C to -80oC. Avoid repeated freeze-thaw cycles.