Mouse Anti-Human NKp46 (Clone B-L46) mAb, Azide Free

Molecule:

NKp46

Synonyms:

Natural cytotoxicity triggering receptor 1, NCR1, NK cell-activating receptor, CD335, Lymphocyte antigen 94 homolog

Species:

Human

Cat. No.:

CDM306B pdf (datasheet)

Quantity/Size:

500 μg

Price:

$650.00 BUY

Concentration:

1 mg/ml

Description:

Natural cytotoxicity receptors (NCRs), are unique markers that regulate natural killer (NK) cell cytotoxicity and cytokine production. The NCR family are comprised of three type I transmembrane (TM) receptors, termed NKp46, NKp44, and NKp30, which are encoded by the genes, NCR1, NCR2, and NCR3, respectively. Even though the NCRs were discovered based on their ability to induce NK cell cytotoxicity of monoclonal antibody (mAb)-coated tumor cell targets, the blocking of individual NCR activity using soluble mAbs had only a mild effect on NK cell cytotoxicity and different tumor cells varied in their susceptibility. Combinations of soluble mAbs to the NCRs were found to have a much stronger blocking effect for selected tumor cell-lines indicating that the NCRs can cooperate with each other to mediate NK cell cytotoxicity of certain tumor cell-types.

Entrez Symbol:

NCR1

Uniprot Name:

Natural cytotoxicity triggering receptor 1

Uniprot ID:

O76036

Data PDF:

CDM306

Specificity:

Recognizes native and recombinant NKp46

Host Species:

Mouse

Immunogen:

Recombinant human NKp46/Fc (CD335)

Isotype:

IgG2a Kappa light chain

Clone:

B-L46

Formulation:

Sterile filtered PBS, carrier and preservative free.

Purification:

Ion exchange chromatography

Application:

FS

Application notes:

Suitable for functional studies. The biological activity is measured by the ability of the coated antibody to induce degranulation of activated NK cells and to enhance IFN-g secretion by non-activated NK.

Storage/Stability:

Store at 2-8°C for up to 1 year or in working aliquots at -20°C to -80oC. Avoid repeated freeze-thaw cycles.