Mouse Anti-Human NKp46 (Clone B-N40) PE mAb

Molecule:

NKp46

Synonyms:

Natural cytotoxicity triggering receptor 1, NCR1, NK cell-activating receptor, CD335, Lymphocyte antigen 94 homolog

Species:

Human

Cat. No.:

CDM300 pdf (datasheet)

Quantity/Size:

100 tests

Price:

$420.00 BUY

Concentration:

100 tests/ml

Description:

Natural cytotoxicity receptors (NCRs), are unique markers that regulate natural killer (NK) cell cytotoxicity and cytokine production. The NCR family are comprised of three type I transmembrane (TM) receptors, termed NKp46, NKp44, and NKp30, which are encoded by the genes, NCR1, NCR2, and NCR3, respectively. Even though the NCRs were discovered based on their ability to induce NK cell cytotoxicity of monoclonal antibody (mAb)-coated tumor cell targets, the blocking of individual NCR activity using soluble mAbs had only a mild effect on NK cell cytotoxicity and different tumor cells varied in their susceptibility. Combinations of soluble mAbs to the NCRs were found to have a much stronger blocking effect for selected tumor cell-lines indicating that the NCRs can cooperate with each other to mediate NK cell cytotoxicity of certain tumor cell-types.

Entrez Symbol:

NCR1

Uniprot Name:

Natural cytotoxicity triggering receptor 1

Uniprot ID:

O76036

Data PDF:

CDM300

Specificity:

Recognizes NKp46, a 26.6 kDa protein

Host Species:

Mouse

Immunogen:

Recombinant human cytotoxicity receptor NKp46

Isotype:

IgG1 Kappa light chain

Clone:

B-N40

Conjugate:

PE

Formulation:

Lyophilized from PBS containing 5% BSA and 0.1% sodium azide.

Purification:

Ion exchange chromatography

Reconstitution:

Reconstitute with 1ml of deionized water.

Application:

FC

Application notes:

Flow Cytometry: Use 10 μl to label 10E6 cells or 100 μl of whole blood.

Storage/Stability:

Stable at 2-8°C for 6 months after reconstitution. DO NOT FREEZE.