Mouse Anti-Human NOX2 Clone 48 mAb

Synonyms:

NADPH oxidase 2, cytochrome b(558) subunit beta, cytochrome b-245 heavy chain, CY24B

Species:

Human

Cat. No.:

CS-MW1842 pdf (datasheet)

Quantity/Size:

1 mg

Concentration:

2.0 mg/ml

Description:

NOX2 ia a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. NOX2 might play a role in signal transduction processes in normal cardiomyocytes.

Entrez Symbol:

CYBB

Uniprot Name:

Cytochrome b-245 heavy chain

Uniprot ID:

P04839

Data PDF:

CS-MW1842

Specificity:

The monoclonal antibody reacts with the purified high molecular weight subunit of cytochrome b558 on Western blots and on blots of whole neutrophil extracts.

Host Species:

Mouse

Immunogen:

Purified cytochrome b558

Isotype:

IgG1

Clone:

48

Formulation:

20 mM TRIS and 150 mM NaCl, pH 8.0 0.1% sodium azide

Purification:

Ammonium sulfate precipitation and gel filtration.

Application:

IHC, WB

Storage/Stability:

Store in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.