Mouse Anti-Human TNF-alpha Clone MAb11 mAb

Molecule:

TNF-alpha/TNFSF1A

Synonyms:

Tumor necrosis factor-α, Cachectin, Necrosin, Macrophage cytotoxic factor (MCF), Differentiation inducing factor (DIF), TNFSF2, TNF-a, TNF-alpha

Species:

Human

Cat. No.:

CSI12341 pdf (datasheet)

Quantity/Size:

0.5 mg

Price:

$415.00 BUY

Concentration:

0.5 mg/ml

Description:

TNF-α is secreted by macrophages, monocytes, neutrophils, T-cells (principally CD4+), and NK-cells. Many transformed cell lines also secrete TNF-α. Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kD. TNF-α forms multimeric complexes; stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.

Entrez Symbol:

TNF

Uniprot Name:

Tumor necrosis factor

Uniprot ID:

P01375

Data PDF:

CSI12340

Host Species:

Mouse

Immunogen:

E. coli-expressed, recombinant human TNF-α

Isotype:

IgG1 kappa light chain

Clone:

MAb11

Formulation:

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Purification:

The antibody was purified by affinity chromatography.

Storage/Stability:

The antibody solution should be stored undiluted at 2-8°C.