Mouse Anti-Human TRAIL / APO2L (Clone B-T24) mAb, Azide Free

Molecule:

TRAIL/APO2L

Synonyms:

Tumor necrosis factor ligand superfamily member 10, Apo-2L, CD253, TNFSF10

Species:

Human

Cat. No.:

CDM080A pdf (datasheet)

Quantity/Size:

200 μg

Price:

$390.00 BUY

Concentration:

1 mg/ml

Description:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Symbol:

TNFSF10

Uniprot Name:

Tumor necrosis factor ligand superfamily member 10

Uniprot ID:

P50591

Data PDF:

CDM080

Specificity:

Recognizes TRAIL, APO2L antigen, a 32 kDa protein

Host Species:

Mouse

Immunogen:

Recombinant human TRAIL

Isotype:

IgG1 Kappa light chain

Clone:

B-T24

Formulation:

Sterile-filtered PBS, treated to remove endotoxins. Carrier and preservative free.

Purification:

Ion exchange chromatography

Application:

ELISA, FC, FS

Application notes:

Inhibits TRAIL induced apoptosis. Recognizes the soluble antigen.

Storage/Stability:

Store at 2-8°C for up to 1 year or in working aliquots at -20°C to -80oC. Avoid repeated freeze-thaw cycles.