Mouse Anti-Human TRAILR3 / DCR1 (Clone B-D44) mAb

Molecule:

TRAILR3/DCR1

Synonyms:

CD263, TRAIL receptor 3, Decoy receptor 1, Decoy TRAIL receptor w/o death domain

Species:

Human

Cat. No.:

CDM240 pdf (datasheet)

Quantity/Size:

200 tests

Price:

$340.00 BUY

Concentration:

100 tests/mL

Description:

Human Trail R3, also called DcR1, CD263, LIT, or TRID is a glycosylphosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. In the Trail receptor family, Trail R3 (DcR1) but also Trail R4 (DcR2) antagonize TRAIL-induced apoptosis whereas Trail R1 (DR4) and Trail R2 (DR5) transduce an apoptosis signal. Trail R3 has extracellular TRAIL-binding cystein-rich domain but lacks intracellular signalling domain. Expression of Trail R3 has been shown to protect cells bearing Trail R1 and/or Trail R2 from Trail-induced apoptosis. Many tumor cell lines don’t express the decoy receptors and are therefore sensitive to TRAIL if they express Trail R1 and/or Trail R2.

Entrez Symbol:

TNFRSF10C

Uniprot Name:

Tumor necrosis factor receptor superfamily member 10C

Uniprot ID:

O14798

Data PDF:

CDM240

Specificity:

Recognises DcR1 (CD263), a 75.90kDa protein

Host Species:

Mouse

Immunogen:

Recombinant Human TRAIL R3/Fc chimera

Isotype:

IgG1K

Clone:

B-D44

Conjugate:

Unconjugated

Formulation:

Liquid in PBS, 1% BSA, 0.09% sodium azide.

Purification:

Afffinity chromatography

Application:

FC

Application notes:

Flow Cytometry: Use 10 μl to label 1x10E6 cells or 100 μl of whole blood.

Storage/Stability:

Stable at 2-8°C for one year. For longer storage, aliquot and store at -20°C to -80°C. Avoid repeated freeze-thaw cycles.