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Native Bovine Plasmin

Molecule:

Plasmin

Synonyms:

LPA, lipoprotein, Lp(a), plasmin

Species:

Bovine

Cat. No.:

CSI19763B pdf (datasheet)

Quantity/Size:

10 mg

Price:

$2,740.00 BUY

Description:

Plasminogen (PLG) is a circulating zymogen that is converted to the active enzyme Plasmin by cleavage of the peptide bond between Arg-560 and Val-561, which is mediated by Urokinase (uPA/PLAU) and Tissue Plasminogen Activator (tPA/PLAT). The main function of Plasmin is to dissolve Fibrin blood clots. Plasmin, like Trypsin, belongs to the family of serine proteases Fibrin is a cofactor for Plasminogen activation by tPA. Urokinase Plasminogen Activator Receptor (uPAR) is a cofactor for Plasminogen activation by uPA. Plasmin is inactivated by Alpha-2-Antiplasmin, a serine protease inhibitor (serpin).

Native Bovine Plasmin is prepared from plasminogen by activation with immobilized human uPA. 100% functionally active plasmin is purified from the activation reaction by immobilized soybean trypsin inhibitor (SBTI). Plasmin will undergo rapid auto proteolysis in the absence of benzamidine and should be used quickly once thawed. Partial cleavage of bovine plasmin between kringles 3 & 4 occurs upon activation, producing a low molecular weight band. This midiplasmin is 100% active.

Concentration:

5 mg/ml

Entrez Symbol:

PLG

Uniprot Name:

Plasminogen

Uniprot ID:

P06868

EC number:

3.4.21.7

Data PDF:

CSI19763

Source:

Bovine plasma

Molecular Weight:

85 kDa

Physical State:

Frozen liquid

Formulation:

Sterile filtered liquid (Frozen) in 0.1 M HEPES, pH 7.4 + 0.1 M NaCl.

Purity:

>95% by SDS-PAGE analysis.

Storage/Stability:

Frozen liquid protein is stable at -80℃C for 3 years from date of delivery. Plasmin will undergo rapid auto proteolysis in the absence of benzamidine and should be used quickly once thawed. Avoid repeated freeze-thaw cycles.