Native Human Alpha-2-Glycoprotein 1, Zinc-Binding

Synonyms:

AZGP1, ZA2G, ZAG, Zn-alpha-2-GP

Species:

Human

Cat. No.:

CRA425C pdf (datasheet)

Quantity/Size:

50 µg

Price:

$1,450.00 BUY

Description:

Zinc-alpha-2-glycoprotein (ZAG) protein stimulates lipid degradation in adipocytes and causes the massive fat losses linked with various advanced cancers. ZAG may bind polyunsaturated fatty acids. It is identical in amino acid sequence to tumor-derived lipid mobilizing factor (LMF), a protein associated with the dramatic loss of adipose body stores in cancer cachexia, and has been shown to stimulate lipolysis by adipocytes in vivo and in vitro. A role for ZAG has been proposed in the regulation of body weight, and age-dependent changes in genetically influenced obesity, and also it regulates melanin production by normal and malignant melanocytes. It has also recently been classified as a novel adipokine in that it is produced by both white and brown fat adipocytes and may act in a local autocrine fashion in the reduction of adiposity in cachexia. Controlling ZAG/LMF's activity could be life-saving in the management of certain cancers and other cachexiainducing conditions, and its possible normal role in body fat store homeostasis.

Entrez Symbol:

AZGP1

Uniprot ID:

P25311

Data PDF:

CRA425

Source:

Human serum

Molecular Weight:

32.14 kDa

Formulation:

Lyophilized 0.4 µm filtered, 0.5 mg/ml solution of 20 mM Tris, 50 mM NaCl, pH 8.0

Purity:

>80% by SDS-PAGE

Amino Acid Sequence:

QENQDGRYSL TYIYTGLSKH VEDVPAFQAL GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS

Storage/Stability:

Store lyophilized protein at 2-8°C for up to 2 weeks for shipping purposes, and -20°C to -80°C for up to 1 year. Once reconstituted, it is stable for several weeks at 2-8°C.