Native Human Haptoglobin 1-1

Molecule:

Haptoglobin

Synonyms:

Hp1-1, HPA1S, HP

Species:

Human

Cat. No.:

CSI14650A pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$425.00 BUY

Description:

Haptoglobin functions to bind free hemoglobin, released from erythrocytes, which allows degradative enzymes to gain access to the hemoglobin while at the same time preventing loss of iron through the kidneys. In clinical settings, the haptoglobulin assay is used to screen for and monitor intravascular hemolytic anemia. Haptoglobin, in its simplest form, consists of two alpha and two beta chains, connected by disulfide bridges. The chains originate from a common precursor protein, which is proteolytically cleaved during protein synthesis. Hp exists in two allelic forms in the human population, so-called Hp1 and Hp2. Three phenotypes of Hp, therefore, are found in humans: Hp1-1, Hp2-1, and Hp2-2. Hp of different phenotype have been shown to bind hemoglobin with different affinities, with Hp2-2 being the weakest binder.

Entrez Symbol:

HP

Uniprot ID:

P00738

Source:

Human plasma

Molecular Weight:

86 kDa

Formulation:

Lyophilized from 0.02 M NH4HCO3.

Purity:

> 95% by SDS-PAGE

Storage/Stability:

Store at -20°C.