Native Human Thyroid Stimulating Hormone, High Purity

Synonyms:

TSH, Thyrotropin

Species:

Human

Cat. No.:

CS078A pdf (datasheet)

Quantity/Size:

100 µg

Description:

Native Human Thyroid Stimulating Hormone is a heterodimeric glycoprotein hormone, comprised of an alpha and beta chain. The alpha chain is shared by glycoprotein hormones: LH, FSH, HCG. TSH is produced by thyrotrope cells in the anterior pituitary gland which regulates the thyroid to produce thyroxine (T4) which is converted to triiodothyronine (T3) in the thyroid, liver and other organs to stimulate metabolism. TSH is secreted throughout life but particularly reaches high levels during the periods of rapid growth and development, as well as in response to stress.

Entrez Symbol:

CGA, TSHB

Uniprot ID:

P01215, P01222

Data PDF:

CS078

Source:

Human pituitary

Formulation:

Lyophilized from 50mM Ammonium Bicarbonate

Purity:

≥ 95% by SDS-PAGE

Biological Activity:

> 8.5 IU, determined by ELISA.

Specific Activity:

8.5 IU/mg (2nd IRP (80/558), WHO) (reference standard: NISBC)

Reconstitution:

Reconstitute using neutral pH buffer of choice. Avoid extreme high and low pH.

Storage/Stability:

Store as supplied for up to 1 year at -20°C to -80°C.