Native Human HMW Urokinase HRP Conjugate

Molecule:

Urokinase

Synonyms:

U-plasminogen activator, uPA

Species:

Human

Cat. No.:

CRU112B pdf (datasheet)

Quantity/Size:

100 μg

Price:

$680.00 BUY

Description:

Urokinase-type Plasminogen Activator is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts Plasminogen to Plasmin by specific cleavage of an Arg-Val bond in Plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (High Molecular Weight uPA). HMW-uPA can be further processed into LMW-uPA (Low Molecular Weight uPA) by cleavage of chain A into a short chain A (A1) and an ATF-uPA (Amino-Terminal Fragment uPA). LMW-uPA is proteolytically active but does not bind to the uPA Receptor (uPAR).

Concentration:

> 1.0 mg/ml, lot specific

Entrez Symbol:

PLAU

Uniprot Name:

Urokinase-type plasminogen activator

Uniprot ID:

P00749

EC number:

3.4.21.73

Data PDF:

CRU112

Source:

Human urine

Molecular Weight:

54 Kda

Physical State:

Liquid

Formulation:

0.05 M Na Acetate, 0.1 M NaCl, 1 mM EDTA, 50% Glycerol, pH 5.0

Purity:

>95% by SDS-PAGE analysis

Storage/Stability:

Store at -80°C