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G proteins are membrane-associated, heterotrimeric proteins composed of three subunits: alpha, beta, and gamma, which together with their receptors (GPCRs) form one of the most prevalent signalling systems in mammalian cells. The G protein alpha subunit, acts as a weak GTPase. GNA16 is the only hetero-trimeric G protein with a restricted expression pattern in hematopoietic cells. Differentiation of promyelocytic cells leads to decreased expression of GNA16. GNA16serves as a marker, in addition to CD34, for hematopoietic progenitor cells.
Note: GNA15 and GNA16 designate the same protein.