Rabbit Anti-Human GNAI2 pAb

Molecule:

GNAI2

Synonyms:

Guanine nucleotide-binding protein G(i) subunit alpha-2, Adenylate cyclase-inhibiting G alpha protein

Species:

Human

Cat. No.:

CPG201 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$280.00 BUY

Description:

Gαi2 is a 40-41 kDa alpha-subunit of heterotrimeric protein, that shares sequence homology with Gαi3 and Gαi1. All these G proteins can be ADP-ribosylated at the carboxy terminal Cys of the CAAX sequence, interfering with receptor coupling. Gαi2 is expressed widely in tissues and cell lines. Activation of PLC-β by Gαi-coupled receptors is the result of release of Gβγ subunits from Gαi. Gαi2 regulates potassium channel activation. Mutation at Arg179 has been identified in tumors. This and the Q205L mutant inhibit adenylyl cyclase.

Entrez Symbol:

GNAI2

Uniprot Name:

Guanine nucleotide-binding protein G(i) subunit alpha-2

Uniprot ID:

P04899

Data PDF:

CPG201

Specificity:

Human Gαi2

Host Species:

Rabbit

Immunogen:

E. Coli expressed human Gαi2 (a.a. 231-351)

Isotype:

IgG

Formulation:

Lyophilized with 0.1% sodium azide.

Reconstitution:

Centrifuge vial prior to opening. Add 200 µl PBS to the vial to fully solubilize the antibody to a concentration of 1 mg/ml.

Application:

IP , WB

Application notes:

Western blot: working dilution of 1:5,000

Storage/Stability:

Store at 2-8°C for short term or in working aliquots at -20°C to -80°C for long term storage. Avoid repeated freeze-thaw cycles.