JavaScript seem to be disabled in your browser.
You must have JavaScript enabled in your browser to utilize the functionality of this website.
Rabbit Anti-Human IKKA polyclonal antibody. IKKα is part of a large protein complex responsible for the inducible phosphorylation of IκB proteins. The same protein was originally identified as CHUK (conserved helix-loop-helix ubiquitous kinase), a serine/threonine kinase of unknown function. The human IKKα is a 85 kDa peptide that has been shown to activate NF-κB by phosphorylation of IκB proteins. IKKα interacts with its upstream kinase, NIK, and its downstream substrate, the IκB proteins. Mutations of IKKα in its kinase domain lead to a dominant-negative phenotype that suppresses TNFα and IL1β induced NF-κB activation.