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Rabbit Anti-Human IKK alpha pAb

Molecule:

IKK-alpha

Synonyms:

Inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B Kinase-alpha, IKKK-A, IKK-alpha, Conserved helix-loop-helix ubiquitous kinase, IKK1, NFKBIKA, TCF-16

Species:

Human

Cat. No.:

CPI201 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$260.00 BUY

Description:

Rabbit Anti-Human IKKA polyclonal antibody. IKKα is part of a large protein complex responsible for the inducible phosphorylation of IκB proteins. The same protein was originally identified as CHUK (conserved helix-loop-helix ubiquitous kinase), a serine/threonine kinase of unknown function. The human IKKα is a 85 kDa peptide that has been shown to activate NF-κB by phosphorylation of IκB proteins. IKKα interacts with its upstream kinase, NIK, and its downstream substrate, the IκB proteins. Mutations of IKKα in its kinase domain lead to a dominant-negative phenotype that suppresses TNFα and IL1β induced NF-κB activation.

Entrez Symbol:

CHUK

Uniprot Name:

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Uniprot ID:

O15111

Data PDF:

CPI201

Specificity:

Human IKK-alpha

Host Species:

Rabbit

Immunogen:

Recombinant human IKK-alpha fragment (aa 557-745)

Isotype:

IgG

Formulation:

Lyophilized from PBS, 0.1% azide.

Purification:

Protein A affinity chromatography

Reconstitution:

Centrifuge vial prior to opening. Add 200 µl sterile distilled water to the vial to fully solubilize the antibody to a concentration of 1 mg/ml.

Application:

IP , WB

Application notes:

Western blot: working dilution of 1:2,000
Immunoprecipitation: working dilution of 1:500

Storage/Stability:

Store at 2-8°C for short term storage or in working aliquots at -20°C to -80°C for long term storage. Avoid repeated freeze-thaw cycles.