Rabbit Anti-Mouse LYVE1 Affinity Purified pAb

Molecule:

LYVE1/XLKD1

Synonyms:

Lymphatic vessel endothelial hyaluronic acid receptor 1, cell surface retention sequence binding protein 1,CRSBP-1,extracellular link domain-containing protein 1

Species:

Mouse

Cat. No.:

PA0846 pdf (datasheet)

Quantity/Size:

50 μg

Price:

$435.00 BUY

Description:

Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein super family. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.

Entrez Symbol:

Lyve1

Uniprot Name:

Lymphatic vessel endothelial hyaluronic acid receptor 1

Uniprot ID:

Q8BHC0

Data PDF:

PA0846

Specificity:

Mouse LYVE-1

Host Species:

Rabbit

Immunogen:

Recombinant Mouse soluble LYVE-1 (aa 24-228) derived from insect cells

Isotype:

IgG

Conjugate:

Unconjugated

Formulation:

Lyophilized from a solution in PBS

Purification:

Antigen Affinity Purified

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water to the vial to fully solubilize the antibody to a concentration 0.1 - 1.0 mg/mL.

Application notes:

ELISA: working dilution of 1-15 µg/mL

WB: working dilution of 2-5 µg/mL

FACS: working dilution of 3-10 µg/mL

IF/IHC: works with cryo-sections

The optimal concentration should be determined by the user for each specific application.

Storage/Stability:

Store as supplied for up to 1 year at at -20°C to -80°C. Reconstitute and store at 2-8°C for up to two weeks or freeze aliquots at -20°C to -80°C for up to six months. Avoid repeated freeze-thaw cycles.