Synonyms:
Interleukin-2, T-cell growth factor, TCGF, lymphokine
Description:
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the
proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes
and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein
complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL
-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which
represents an unusual regulatory mode for controlling the precise expression of a single
gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative
colitis-like disease that suggests an essential role of this gene in the immune response to
antigenic stimuli.
Uniprot Name:
Interleukin-2
Purity:
>95%, SDS-PAGE analysis
Specificity:
Recognizes native and recombinant rat IL-2
Immunogen:
Purified recombinant rat IL-2
Formulation:
The immunoglobulin is in phosphate buffered saline, pH 7.3 and is 0.22 micron sterile filtered. The endotoxin level is < 0.1 ng/µg of protein.
Purification:
Purified from rabbit serum by protein A/G affinity chromatography
Application:
DB , ELISA, WB
Storage/Stability:
Store at -20°C. Avoid repeated freeze-thaw cycles. Handle product under aseptic conditions at all times. For long term storage, sodium azide should be added as a preservative.
