Rabbit Anti-Rat TYROBP / DAP12 pAb

Molecule:

DAP12

Synonyms:

TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killeractivating receptor-associated protein, KAR-associated protein.

Species:

Rat

Cat. No.:

CPD001 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$280.00 BUY

Description:

DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is a disulfide-bonded homodimer. Crosslinking of DAP12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.

Uniprot Name:

TYRO protein tyrosine kinase-binding protein

Uniprot ID:

Q6X9T7

Data PDF:

CPD001

Specificity:

Recombinant and native rat DAP12

Host Species:

Rabbit

Immunogen:

E. coli-expressed DAP12 peptide (amino acids 28-40)

Isotype:

IgG

Formulation:

Lyophilized with 0.1% sodium azide.

Purification:

Protein G affinity chromatography.

Reconstitution:

Centrifuge vial prior to opening. Reconstitute to 1 mg/ml by adding 200 µl PBS.

Application:

WB

Application notes:

Western blot: working dilution of 1:1,000.

Storage/Stability:

Store at 2-8°C for short term storage or at -20°C to -80°C in working aliquots for long term storage. Avoid repeated freeze-thaw cycles.