Rat Anti-Mouse IL-6 Clone MP5-32C11 mAb

Molecule:

IL-6

Synonyms:

Interleukin-6, B-cell hybridoma growth factor, Interleukin HP-1

Species:

Mouse

Cat. No.:

MON5017 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$1,010.00 BUY

Description:

The antibody neutralizes mouse interleukin 6 (IL-6). It does not cross-react with LPS (the component of the bacterial cell wall which is considered responsible for the toxicity of gram-negative bacteria) and TNF-alpha nor does it block human or rat IL-6 in proliferation assays using the KD83 cell line. MP5-32C11 inhibits mouse IL-6-induced proliferation of the NFS60 myelomonocytic cell line and KD83 plasmacytoma.

IL-6 is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severe infection and regulates the immune response, acute phase reaction and hematopoiesis. IL-6 plays a critical role in B cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. Continuous IL-6 gene expression makes an essential contribution to a multistep oncogenesis of plasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number of antibody producing hybridomas.

Uniprot Name:

Interleukin-6

Uniprot ID:

P08505

Data PDF:

MON5017

Specificity:

Native and recombinant mouse IL-6

Host Species:

Rat

Immunogen:

Recombinant mouse IL-6

Isotype:

IgG2a

Clone:

MP5-32C11

Formulation:

Lyophilized from sterile-filtered PBS, pH 7.2

Reconstitution:

Reconstitute the vial by injection of 0.5 ml sterile de-ionized water (Caution: vial is under vacuum).

Application:

ELISA, FC, IP , WB

Application notes:

Functional studies, neutralizes IL-6, Western blot, ELISA, Immunoprecipitation

Storage/Stability:

Lyophilized product should be stored at 2-8°C for up to 1 year. Store reconstituted solution in aliquots at -20°C to -80°C. Avoid repeated freeze/thaw cycles.