Rat Anti-Mouse TNF-alpha Clone 6B8 LE/NA mAb

Synonyms:

Tumor necrosis factor-α, Cachectin, Necrosin, Macrophage cytotoxic factor (MCF), Differentiation inducing factor (DIF), TNFSF-2, TNF-a, TNF-alpha

Cat. No.:

CSI11553 pdf (datasheet)

Quantity/Size:

0.5 mg

Price:

$595.00 BUY

Concentration:

1.0 mg/mL

Description:

The 6B8 rat monoclonal antibody recognizes mouse tumor necrosis factor-α (TNF-α). TNF-α is secreted by macrophages, monocytes, neutrophils, T-cells and NK-cells. Many transformed cell lines also secrete TNF-α. Monomeric mouse TNF-α is 156 amino acid protein (N-glycosylated) with a reported molecular weight of 17.5 kDa. TNF-α forms multimeric complexes; stable trimers are most common in solution. A 26 kD membrane form of TNF-α has been described. TNF-α binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.

Uniprot ID:

P06804

Data PDF:

CSI11552

Purity:

>95% by SDS-PAGE

Specificity:

Mouse and rat TNF-α

Host Species:

Rat

Immunogen:

Recombinant mouse TNF-α

Isotype:

IgG1K

Clone:

6B8

Conjugate:

Unconjugated

Formulation:

Liquid in PBS, pH 7.2. No preservative.

Purification:

Affinity Chromatography

Application:

ELISA, ELISPOT

Storage/Stability:

Store at 2-8 °C. Handle under aseptic conditions. DO NOT FREEZE.