Rat Anti-Mouse VEGFR2/KDR Agonistic mAb

Molecule:

VEGFR-2/KDR

Synonyms:

Vascular endothelial growth factor receptor 2, VGFR2, CD309, Fetal liver kinase 1, FLK

Species:

Mouse

Cat. No.:

CMV127 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$1,290.00 BUY

Description:

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis. The antibody will bind near the ligand binding site of the receptor and has agonistic activity.

Uniprot Name:

P35918

Data PDF:

CMV127

Specificity:

Mouse VEGFR2

Host Species:

Rat

Immunogen:

Mouse VEGFR2 N-terminal fragment (aa 30-200)

Isotype:

IgG2a

Clone:

3D09

Formulation:

Lyophilized

Purification:

Protein G affinity chromatography

Storage/Stability:

2-8°C for short term storage. Store as supplied for up to 1 year at -20°C to -80°C. Upon reconstitution, prepare working aliquots and store at -20°C to -80°C.