Recombinant Human Activin A

Synonyms:

INHBA, Inhibin beta A chain, Erythroid differentiation protein, EDF, Activin beta-A chain

Species:

Human

Cat. No.:

CRA400B pdf (datasheet)

Quantity/Size:

10 μg

Price:

$520.00 BUY

Description:

Activin A is a TGF-ß family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-ß antagonist, follistatin.

Entrez Symbol:

INHBA

Uniprot ID:

P08476

Data PDF:

CRA400B

Source:

Insect cells

Molecular Weight:

26.0 kDa, disulfide-linked homodimer, 116 aa /subunit

Formulation:

Lyophilized from 10 mM Sodium citrate, pH 3.0.

Purity:

> 97% by SDS-PAGE and HPLC analyses

Biological Activity:

ED50 ≤ 2 ng/ml, determined by the ability to inhibit the proliferation of mouse MPC-11 cells.

Specific Activity:

> 5 x 10e5 units/mg

Endotoxin Level:

< 1 EU/µg

Amino Acid Sequence:

GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFH STVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Storage/Stability:

Stable at -20°C to -80° for up to 1 year.