Recombinant Human Amphiregulin (AREG) Animal Free

Synonyms:

Recombinant Human Amphiregulin, AREG, Colorectum cell-derived growth factor, CRDGF, Schwannoma-derived growth factor, SDGF

Species:

Human

Cat. No.:

CS273C-AF pdf (datasheet)

Quantity/Size:

1 mg

Price:

$1,560.00 / Special Price: $1,200.00 BUY

Description:

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity.

Manufactured without Animal-derived products, in an Animal Free facility.

Entrez Symbol:

AREG

Uniprot ID:

P15514

Data PDF:

CS273-AF

Source:

E. coli

Molecular Weight:

10.1 kDa, (87 aa) monomer

Physical State:

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation:

Lyophilized from a 0.2 μm filtered solution containing 10 mM sodium phosphate, pH 7.5.

Purity:

>95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 ≤ 20 ng/ml, determined by proliferation of murine 3T3 cells.

Specific Activity:

≥ 5.0 ×104 Units/mg.

Endotoxin Level:

≤1 EU/μg determined by kinetic LAL analysis

Amino Acid Sequence:

SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMK

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.