Recombinant Human Apolipoprotein A-I

Molecule:

APOA1

Synonyms:

Apolipoprotein A-I, ALP-1, APOA, APOA-1, Apo-AI, ApoA-I, LTW-1, SEP-1, SEP-2

Species:

Human

Cat. No.:

CRA405B pdf (datasheet)

Quantity/Size:

100 μg

Price:

$515.00 BUY

Description:

Apolipoprotein A-I (APOA1) is produced in the liver and intestine, and secreted as the predominant constituent of nascent high density lipoprotein (HDL) particle. APOA1, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This APOA1 ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is thought to inhibit arterogenesis. For this reason HDL is also known as the “good cholesterol.” The therapeutic potential of APOA1 has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of APOA1 (called apoA-I Milano). The availability of recombinant normal APOA1 should facilitate further investigation into the potential usefulness of APOA1in preventing atherosclerotic vascular diseases.

Recombinant Human APOA1 is a 28.2 kDa protein of 244 amino acid residues.

Entrez Symbol:

APOA1

Uniprot Name:

Apolipoprotein A-I

Uniprot ID:

P02647

Genbank Accession No:

NM_000039

Source:

E. coli

Molecular Weight:

28.2 kDa

Physical State:

Lyophilized

Formulation:

Lyophilized from a sterile filtered solution without additives.

Purity:

>97% by SDS-PAGE

Endotoxin Level:

<0.1 ng/�g

Storage/Stability:

Store desiccated at -20 °C