Recombinant Human Apolipoprotein E4

Molecule:

APOE

Synonyms:

Apolipoprotein E4, AD2, Apo-E, APOEA

Species:

Human

Cat. No.:

CRA404C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$490.00 BUY

Description:

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease.

Entrez Symbol:

APOE

Uniprot ID:

P02649 VAR_000652

Data PDF:

CRA404

Source:

E. coli

Molecular Weight:

34.4 kDa

Physical State:

Lyophilized

Formulation:

10 mM sodium phosphate, 0.5 mM DTT, pH 7.5

Purity:

>90% by reducing and non-reducing SDS-PAGE

Endotoxin Level:

< 5 EU/µg

Amino Acid Sequence:

GPKVEQAVET EPEPELRQQT EWQSGQRWEL ALGRFWDYLR WVQTLSEQVQ EELLSSQVTQ ELRALMDETM KELKAYKSEL EEQLTPVAEE TRARLSKELQ AAQARLGADM EDVRGRLVQY RGEVQAMLGQ STEELRVRLA SHLRKLRKRL LRDADDLQKR LAVYQAGARE GAERGLSAIR ERLGPLVEQG RVRAATVGSL AGQPLQERAQ AWGERLRARM EEMGSRTRDR LDEVKEQVAE VRAKLEEQAQ QIRLQAEAFQ ARLKSWFEPL VEDMQRQWAG LVEKVQAAVG TSAAPVPSDN H

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.