Recombinant Human Artemin

Synonyms:

Enovin, neublastin, ARTN

Species:

Human

Cat. No.:

CRA001C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$2,720.00 / Special Price: $2,100.00 BUY

Description:

Artemin is a member of the glial cell line-derived neurotrophic factor (GNDF) ligand family. Artemin is a ligand for the receptor complex, GFRalpha3-RET, as well as activates the GFRalpha1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.

Entrez Symbol:

ARTN

Uniprot ID:

Q5T4W7

Data PDF:

CRA001

Source:

E. coli

Molecular Weight:

12.0/23.9 kDa (113/226 aa) Non-glycosylated, disulfide-linked homodimer

Physical State:

Lyophilized

Formulation:

Sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, 25 mM sodium chloride, pH 4.5

Purity:

≥95%, determined by reducing and non-reducing SDS-PAGE

Biological Activity:

The activity is determined by the dose-dependant proliferation of the SH-SY5Y cell line and is typically 4-8 ng/mL. The activity can also be determined by its ability to promote survival and neurite outgrowth.

Endotoxin Level:

≤ 1 EU/μg by kinetic LAL analysis

Amino Acid Sequence:

AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG

Reconstitution:

Centrifuge vial prior to opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a c

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.