Recombinant Human BD1 (36 aa)

Molecule:

BD-1

Synonyms:

DEFB1, Beta-defensin 1

Species:

Human

Cat. No.:

CRB501B pdf (datasheet)

Quantity/Size:

20 μg

Price:

$520.00 BUY

Description:

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alphadefensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the Cterminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.

Entrez Symbol:

DEFB1

Uniprot ID:

P60022

Data PDF:

CRB501

Source:

E. coli

Molecular Weight:

3.9 kDa (36 aa)

Formulation:

Lyophilized from a sterile-filtered solution without additives.

Purity:

95% as determined by SDS-PAGE and HPLC analyses

Biological Activity:

Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100-1,000 ng/ml.

Endotoxin Level:

< 1 EU/µg

Amino Acid Sequence:

DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK

Storage/Stability:

Stable at -20°C to -80° for up to 1 year