Recombinant Human BMP-4 active

Molecule:

BMP-4

Synonyms:

BMP4, BMP2B, BMP2B1, bone morphogenetic protein 4

Cat. No.:

CRC404C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$5,920.00 / Special Price: $3,880.00 BUY

Description:

BMP-4 is a member of the bone morphogenetic protein family which is part of the TGF-β superfamily of structurally related signaling proteins. Like other bone morphogenetic proteins, BMP-4 promotes bone and cartilage development, specifically tooth and limb development and fracture repair. BMP-4 is a critical signaling molecule required for early differentiation of the human embryo and establishing a dorsal ventral axis. Recombinant human BMP-4 is a disulfide-linked homodimer consisting of two 13.1 kDa, glycosylated, polypeptide chains, each containing 116 amino acids.

Uniprot ID:

P12644

Source:

CHO cells

Molecular Weight:

13.1/26.2 kDa predicted (homodimer, 116 aa each)

Formulation:

Lyophilized from a sterile filtered solution containing 0.1% Trifluoroacetic Acid (TFA).

Purity:

>95% by reducing and non-reducing SDS-PAGE

Biological Activity:

The ED50 as determined by dose-dependent induction of alkaline phosphatase activity of ATDC-5 cells is in the range of 2-12 µg/ml.

Specific Activity:

≥ 6.7 x 10^4 units/mg

Amino Acid Sequence:

SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAI VQT LVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR

Storage/Stability:

Store at -20°C to -80°C