Recombinant Human BMPR-1A / ALK-3, Fc Tag

Synonyms:

Activin receptor-like kinase 3, ALK3; Serine/threonine-protein kinase receptor R5, SKR5; CD292; ACVRLK3; 10q23del

Cat. No.:

CRC405C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$3,780.00 / Special Price: $2,480.00 BUY

Description:

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. This product contains the first 152 amino acids of the extracellular portion of BMPR-1A and can be used to interfere with or neutralize ligand signaling. The product contains a C-terminus linker (IEGRMD) and an Fc tag (Human IgG1).

Uniprot ID:

P36894

Data PDF:

CRC405

Source:

CHO cells

Molecular Weight:

Dimer, 40.4/80.8 kDa predicted (with 362/724 amino acids.)

Formulation:

Lyophilized from a sterile aqueous solution containing PBS

Purity:

>95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 ≤ 120 ng/mL as determined by inhibition of human BMP-4-induced alkaline phosphatase production by ATDC5 cells

Specific Activity:

≥ 8.3 x 10^3 units/mg

Amino Acid Sequence:

QNLDSMLHGT GMKSDSDQKK SENGVTLAPE DTLPFLKCYC SGHCPDDAIN NTCITNGHCF AIIEEDDQGE TTLASGCMKY EGSDFQCKDS PKAQLRRTIE CCRTNLCNQY LQPTLPPVVI GPFFDGSIRI EGRMDDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK

Storage/Stability:

Store at -20°C to -80°C