Recombinant Human BMP11 / GDF11

Synonyms:

GDF-11, BMP-11, Bone Morphogenetic Protein-11, Growth Differentiation Factor-11

Species:

Human

Cat. No.:

CRG403B pdf (datasheet)

Quantity/Size:

20 μg

Price:

$520.00 BUY

Description:

GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity.

Entrez Symbol:

GDF11

Uniprot ID:

O95390

Data PDF:

CRG403B

Source:

E. coli

Molecular Weight:

25.0 kDa (109 aa)

Formulation:

Lyophilized from PBS

Purity:

> 98% as determined by SDS-PAGE and HPLC analyses

Biological Activity:

ED50 typically 0.08-0.1 µg/ml, determined by its ability to inhibit induced alkaline phosphatase productiion by ATDC-5 chondrogenic cells.

Endotoxin Level:

< 1 EU/µg

Amino Acid Sequence:

NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS

Storage/Stability:

Stable for 1 year at -20°C to -80°C.