Recombinant Human Cardiotrophin-like Cytokine Factor 1

Synonyms:

CLCF1, B-cell-stimulating factor 3, BSF-3, Novel neurotrophin-1, NNT1

Species:

Human

Cat. No.:

CRN502B pdf (datasheet)

Quantity/Size:

10 μg

Price:

$520.00 BUY

Description:

Recombinant Human Cardiotrophin-like Cytokine Factor 1 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, CLCF1 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-beta) and induces tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, CLCF1 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM.

Entrez Symbol:

CLCF1

Uniprot Name:

Recombinant Human Cardiotrophin-like Cytokine Factor 1

Uniprot ID:

Q9UBD9

Data PDF:

CRN502

Source:

E. coli

Molecular Weight:

22.4 kDa (199 aa)

Formulation:

Lyophilized from PBS

Purity:

> 98% by SDS-PAGE and HPLC analyses

Biological Activity:

Weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.

Endotoxin Level:

< 1 EU/µg

Amino Acid Sequence:

MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF

Storage/Stability:

Stable for 1 year at -20°C to -80°C.